Adults (male or female) aged 18 years to 80 years with a clinical diagnosis of prurigo nodularis (PN) for at least 6 months, may qualify to participate. Individuals must have nodular lesions on the upper limbs, trunk, and/or lower limbs with at least 20 nodules on the entire body, distributed bilaterally (on both sides). Moderate to severe disease must be present, as well as severe pruritus (itch).
Participants will receive investigational medication (active study drug) or placebo, via injection. At Week 16 everyone will be investigational medication (active study drug)
Investigational medication and study-related care will be provided at no cost. Reimbursement for study-related expenses may be provided.