Adults aged 18 to 75 years old with severe chronic hand eczema (CHE), may qualify to participate. Individuals must have a history of severe CHE for at least 6 months and a body mass index (BMI) of 35 kg/m2 or less. Hand eczema resistant to high potency or ultra-high potency topical corticosteroids used in the past year, is also required.
Participants will receive investigational oral medication (active study drug) or placebo during the initial treatment period (part A). During the second treatment period (part B), those individuals who previously received placebo will receive active study drug. Use of an emollient throughout the duration of the study is required. Investigational medication and study-related care will be provided at no cost. Reimbursement for study-related expenses may be provided.
Study participation will last about 40 weeks and involve about 13 visits to the study centre.
Email Tina Craig, Clincal Research Coordinator at DermEffects to register.